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Advancing pre-clinical cardiometabolic research

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Publications

Most recent publications highlighting our capabilities

Obesity-induced mesenteric PVAT remodelling is sexually dimorphic, but not driven by ovarian hormones

Lisa Ivatt, Mhairi Paul, Allende Miguelez-Crespo, Patrick W. F. Hadoke, Matthew A. Bailey, Ruth A. Morgan & Mark Nixon.

Cardiovascular Diabetelogy. 2025 Jan 24.

PMID: 39856754

The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure

Luke D Boyle, Allende Miguelez-Crespo, Mhairi Paul, Elisa Villalobos, Julia NC Toews, Lisa Ivatt, Boglarka Nagy, Marisa Magennis, Natalie ZM Homer, Ruth Andrew, Victor Viau, Geoffrey L Hammond, Roland H Stimson, Brian R Walker & Mark Nixon.

Nat Communications. 2025 Jan 09.

PMID: 39788946

Evaluation of Candidate “Kill or Cure” Strategies to Treat MFN2-related Lipodystrophy.

Ineke Luijten, Xiong Weng, Ula Kibildyte, Jana Buchan, Ami Onishi, Jake Mann, Eleanor McKay, David Savage, Robert K. Semple.

bioRxiv 2025.01.01.630797

The metabolically protective energy expenditure increase of Pik3r1-related insulin resistance is not explained by Ucp1-mediated thermogenesis.

Ineke Luijten, Ami Onishi, Eleanor J. McKay, Tore Bengtsson, Robert K. Semple.

bioRxiv 2024.02.12.579851

ATP-binding cassette family C member 1 constrains metabolic responses to high-fat diet.

Elisa Villalobos, Allende Miguelez-Crespo, Ruth A Morgan, Lisa Ivatt, Mhairi Paul, Joanna P Simpson, Natalie ZM Homer, Dominic Kurian, Judit Aguilar, Rachel Kline, T Wishart, Nicholas Morton, Roland H Stimson, Ruth Andrew, Brian R Walker, Mark Nixon.

J Endocrinol. 2024 Jun 1:JOE-24-0024.

PMID: 38829241

Mesenchymal-specific Alms1 knockout in mice recapitulates metabolic features of Alström syndrome.

Eleanor J McKay, Ineke Luijten, Xiong Weng, Pablo B Martinez de Morentin, Elvira De Frutos González, Zhanguo Gao, Mikhail G Kolonin, Lora K Heisler, Robert K Semple.

Mol Metab. 2024 Jun:84:101933

PMID: 38583571

Deletion of Hsd11b1 suppresses caloric-restriction-induced bone marrow adiposity in male but not female mice.

Andrea Lovdel, Karla Suchacki, Fiona Roberts, Richard J Sulston, Robert J Wallace, Benjamin J Thomas, Rachel M B Bell, Iris Pruñonosa Cervera, Gavin Macpherson, Nicholas Morton, Natalie ZM Homer, Karen E Chapman, William P Cawthorn.

J Endocrinol. 2024 May 1:JOE-24-0072.

PMID: 38805506

The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent.

Karla J Suchacki, Benjamin J Thomas, Yoshiko M Ikushima, Kuan-Chan Chen, Claire Fyfe, Adriana AS Tavares, Richard J Sulston, Andrea Lovdel, Holly J Woodward, Xuan Han, Domenico Mattiucci, Eleanor J Brain, Carlos J Alcaide-Corral, Hiroshi Kobayashi, Gillian A Gray, Phillip D Whitfield, Roland H Stimson, Nicholas M Morton, Alexandra M Johnstone, William P Cawthorn.

Elife. 2023 Apr 25:12:e88080.

PMID: 37096321

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Centre for Cardiovascular Science

Edinburgh BioQuarter

Edinburgh, EH16 4TJ

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