Energy Homeostasis
Sable Systems Promethion Core
The Sable Systems Promethion platform is a cutting-edge tool for in-depth assessment of murine in vivo physiology, specifically targeting indirect calorimetry and energy expenditure. Utilizing highly sensitive gas analysers, it enables continuous measurement of oxygen consumption (VO2) and carbon dioxide production (VCO2). This information is crucial for calculating respiratory exchange ratios (RQ), shedding light on fuel utilisation patterns.
Additionally, the platform integrates features for monitoring food and water intake, providing insights into nutritional behaviours. Simultaneously, the system tracks locomotion and exercise, offering a comprehensive understanding of energy balance. With mice housed in metabolic chambers, this technology enables extended, real-time observations, facilitating nuanced investigations into metabolic health and contributing significantly to research on metabolic diseases.
Our setup allows simultaneous capture of data from up to 16 experimental mice at any one time. For more information and training, please contact us.